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KMID : 0043320190420040326
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Archives of Pharmacal Research
2019 Volume.42 No. 4 p.326 ~ p.331
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Cytotoxic isocoumarin derivatives from the mangrove endophytic fungus Aspergillus sp. HN15-5D
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Wu Yingnan
Chen Senhua
Liu Hongju
Huang Xishan
Liu Yayue
Tao Yiwen
She Zhigang
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Abstract
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Five isocoumarin derivatives including three new compounds, aspergisocoumrins A?C (1?3), together with two known analogues, 8-dihydroxyisocoumarin-3-carboxylic acid (4) and dichlorodiaportin (5) were obtained from the culture of the endophytic fungus Aspergillus sp. HN15-5D derived from the fresh leaves of the mangrove plant Acanthus ilicifolius. Their structures were elucidated using comprehensive spectroscopic methods. The double bond geometry of compounds 1 and 2 were assigned as E and Z on the basis of the distinct coupling constants, respectively. Compounds 1 and 2 showed cytotoxicity against MDA-MB-435 with IC50 values of 5.08?±?0.88 and 4.98?±?0.74 μM, respectively.
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KEYWORD
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Isocoumarins, Cytotoxicity, Aspergillus sp., Mangrove endophytic fungus
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